The top teams do have players getting a lot of minutes but they rotate too. For instance a quick check of the stats shows Xhaka has played more minutes this season than Citys mids, Liverpools, United, etc in fact the only mid at our rivals I could find in my quick and dirty search that played more was Hjoberg and he had a ridiculous amount of minutes for Denmark for some reason. Saka and Martinelli aren't far behind Xhaka either which is even more of a concern to me given their ages. You can probably push the likes of White quite hard as he is at peak age and has no real history of injury, Xhaka probably falls into that category too, and Gabriel but after that I'd be less convinced. All our fullbacks (bar White) are crocks. Parteys been a crock since we signed him. Saliba, Saka, Martinelli, etc are too young to be pushing to these limits. Odegaard seems to get a bit more protection but I can see why, his stamina isn't at its peak yet, especially for the work he does.
I really thing we should rotate a lot more. Especially in the Europa and with earlier subs. I also think we spend so much on guys like Lokonga and Vieira that they just have to be used. Same goes for Eddie with the wage he's on. The trust has already been placed in them, its not acceptable to withdraw that trust when the going gets tough. This is Artetas squad, they're his guys, its up to him to figure it out.