The major differences seem to be on the ongoing culture wars in the US and hopefully a Biden presidency will focus on the social unrest, by all accounts that was his motivation to even go back in the ring this time around.
But in terms of policy there isn't a huge difference - they have the same approach on China (more aggresion), the Middle East (less intervention) and South East Asia (more collaboration). Biden will probably stop kicking Europe and NATO around publicly but the US as a whole will be less interest Europe by the end of this decade, regardless of who is in charge. I suppose Biden will play nice in multilateral institutions which will be well received since the rest of the G7 are terrified of a world where they need to step up.
Economically, Biden will probably accelerate the step towards renewables and clean energy which is a good thing - however market forces are driving that change compared to 10 years ago and there's gradually going to be plenty of powerful billionaires lobbying for control on that side of the spectrum too. I suspect he'll help the process by not getting in the way which is still a net positive. There's going to be a fair chunk of money being injected into the US as 'stimulus' - if it's Trump it'll be in the form of a new infrastructure bill and if it's the Democrats it'll be in the form of a watered down Green New Deal. And the Fed and Treasury are lock step in terms of policy regardless of who is in charge.
Ultimately I don't feel like there will be material changes but the middle class don't have to read uncomfortable headlines of the President saying openly racist or bigoted things so we'll feel better about not having to think too much about what's going wrong. I think Biden's best chance of doing anything memorable is to try and heal social divisions and accelerate progress towards a cleaner America - in theory those should be low hanging fruit but I don't think he's really got the power to make any significant socio-economic changes. I dare say no President can at this stage.
