That the question is being asked says it all really. My answer's yes, it won't be like for like but I think we'll have what we need, or more precisely continue to have similar lacks.
Would never have dreamed of admitting that before the start of the season but Wilshere has proven to be far, far more ready to take on responsibility and excel than I expected.
Some other questions:
Will Ramsey return well from injury?
How will the club and Wenger react if (when) Fabregas departs?
What will Arsenal do to prevent the likes of Wilshere and Ramsey leaving to play out their careers at other clubs?
If either of these two end up doing a Cole on us ...