For me the most important thing is less to rest the first XI—except maybe those that are in dire need—but to give some proper minutes to the benchwarmers and let them own the result.
Kepa, Nwaneri, Skelly, Hincapié, Mosquera, White, Nørgaard, Dowman, none of these dudes is playing enough in the league and all of them should start. If they don't get to run out a few matches they won't know up from down when they're needed.
I'd play @RowJimmy's XI, but I'd drop Merino for Martinelli and give the latter a good free hit as a central forward and have Rice at the ready to sub in for Eze if we're looking a bit too porous.