I'd go with this:
-------------Gyokeres
Trossard-------Eze------Nwaneri
----------Merino-Norgaard-----
MLS--Hincapie----Mosquera-White
---------------Kepa
3 of our front 4 started against Palace, so that'd likely help going forward as they wouldn't look like complete strangers.
This match could suit Gyokeres as Brighton will likely play a high line. I'd rest him against Prague and go with either Merino or Martinelli (if fit).
Tempted to start Gabriel instead of Hincapie as he's probably not match fit. 30 minutes today and then a start in the CL next week is probably better. However with Saliba's injury, we should be cautious with playing Gabriel.
Bring on Zubi , Rice, Saka et al in the 2nd half if need be as we really need to progress. We have a very big squad so staying in this competition could keep everyone sharp and motivated. And there's also a trophy to be won in the end.