Mourinho has always gained the upper hand on Wenger thanks to us fielding one or two idiots who inevitably bring the system down. The likes of Senderos, Flamini etc. Wenger will be keen to rectify this. I think we will see at least one big shift in line-up. Sanchez will most likely be on the bench.
And you have to tinker with the team to absorb injuries. We are so used to Wenger keeping it simple and miss out on tactical football. Chelsea won the league playing Aspicueleta a right footed player, at left back because he was stronger than their available left backs. Also Ivanovich went from a centre back to a right back. It's these pragmatic shifts in approach that win you titles. We have a long standing system and we make the players fit rather than sometimes changing the system to fit players when the need arises. This is why you are unlikely to see us play 3 at the back under Wenger. On second thought it should be a credible option tomorrow.