Coquelin out should have Wenger thinking. By the way, is there any confirmation that Coquelin is indeed out? When I saw how he landed I was instantly concerned; I worried about a serious knee injury. Since he was withdrawn from the game, there is at least minor injury to one or more ligaments in his knee.
Anyway, Wenger witnessed first hand against Zagreb that Arteta and Cazorla in midfield is a crap combination. After the West Ham debacle Wenger went conservative and reverted back to what worked decently at the back end of last season. I wonder if he will now revert back to the midfield pairing he favored before that, Ramsey and Arteta? The alternative is Ramsey and Cazorla, which for my money is likely to be found wanting as well.