I've noticed some XHRs fail from the site when the user is at www.onemoreinthetolly.com instead of onemoreinthetolly.com or vice versa - the site thinks it's a cross domain call and rejects it because the right CORS headers aren't there.
You might see this with "quick reply" features, quotes, and adding rep - pretty much any JavaScript-based operation that doesn't reload the page.
I was able to resolve it temporarily by switching from the www. to the non-www. URL the other day, which allowed me to add +1 to Chili after the main page had fucked up for some reason.